What Does Brown Spots On Your Legs Mean?

26.07.2023 0 Comments

What Does Brown Spots On Your Legs Mean
Brown Spots Can Appear on the Legs for Many Reasons. – Pigmentation on the legs can be age spots or dark spots caused by sun exposure over a period of time. In more serious cases, these brown spots can be an early symptom of an underlying condition such as chronic venous insufficiency.

What is the cause of brown spots on my legs?

What food causes dark spots on legs? – The main reasons for dark spots are sun exposure, diabetes, skin cancer, post-inflammatory hyperpigmentation, and Addison’s Disease but there is one more thing to add to that list: food. There are certain foods that you should avoid in order to decrease your risk for developing dark spots.

What do brown spots on lower legs mean?

Chronic Vein Disease – In addition to its unsightly appearance, hemosiderin staining indicates an underlying health condition. The reddish-brown discoloration on the lower legs is caused by chronic venous disease–the abnormal function of veins. When your veins can’t pump blood back up to the heart properly, it pools in your lower legs.

High blood pressure – veins force blood through the veins and sometimes through the skin. Vein ulcers – slow-healing or non-healing wounds.

As blood continues to pool in the veins, its cells break down and leak iron pigments into the skin. Over time, this shows up as brown patches or stains on the lower leg or ankle. When unaddressed, the stain will darken and eventually may turn black. At this point, these symptoms are unfortunately permanent even when vein disease is treated.

How do you get rid of brown spots on your legs?

Diagnosing age spots might include:

Visual inspection. Your doctor can usually diagnose age spots by looking at your skin. It’s important to distinguish age spots from other skin disorders because the treatments differ and using the wrong procedure may delay other needed therapy. Skin biopsy. Your doctor might do other tests, such as removing a small sample of skin for examination in a lab (skin biopsy). This can help distinguish an age spot from other conditions, such as lentigo maligna, a type of skin cancer. A skin biopsy is usually done in a doctor’s office, using a local anesthetic.

If you want your age spots to be less noticeable, treatments are available to lighten or remove them. Because the pigment is located at the base of the epidermis — the topmost layer of skin — any treatments meant to lighten the age spots must penetrate this layer of skin. Age spot treatments include:

Medications. Applying prescription bleaching creams (hydroquinone) alone or with retinoids (tretinoin) and a mild steroid might gradually fade the spots over several months. The treatments might cause temporary itching, redness, burning or dryness. Laser and intense pulsed light. Some laser and intense pulsed light therapies destroy melanin-producing cells (melanocytes) without damaging the skin’s surface. These approaches typically require two to three sessions. Wounding (ablative) lasers remove the top layer of skin (epidermis). Freezing (cryotherapy). This procedure treats the spot by using a cotton-tipped swab to apply liquid nitrogen for five seconds or less. This destroys the extra pigment. As the area heals, the skin appears lighter. Spray freezing may be used on a small grouping of spots. The treatment may temporarily irritate the skin and poses a slight risk of permanent scarring or discoloration. Dermabrasion. Dermabrasion sands down the surface layer of skin with a rapidly rotating brush. New skin grows in its place. You may need to undergo the procedure more than once. Possible side effects include temporary redness, scabbing and swelling. It may take several months for pinkness to fade. Microdermabrasion. Microdermabrasion is a less aggressive approach than dermabrasion. It leaves mild skin blemishes with a smoother appearance. You’ll need a series of procedures over months to get modest, temporary results. You may notice a slight redness or stinging sensation on the treated areas. If you have rosacea or tiny red veins on your face, this technique could make the condition worse. Chemical peel. This method involves applying a chemical solution to the skin to remove the top layers. New, smoother skin forms to take its place. Possible side effects include scarring, infection, and lightening or darkening of skin color. Redness lasts up to several weeks. You might need several treatments before you notice any results.

The age spot therapies that remove skin are usually done in a doctor’s office and don’t require hospitalization. The length of each procedure and the time it takes to see results varies from weeks to months. After treatment, when outdoors you’ll need to use a broad-spectrum sunscreen with a sun protection factor (SPF) of at least 30 and wear protective clothing.

Why do I suddenly have brown spots on my skin?

Changes in skin pigmentation can happen for many reasons, including birthmarks, pigmentation disorders, rashes, and infections. An increase in melanin, for example, can cause brown or dark patches to appear. Skin contains melanin, which is the pigment that gives the skin its color.

  1. Having more melanin makes the skin darker, while less of it results in lighter skin.
  2. Melanin is also responsible for hair and eye color.
  3. Patches of discolored skin are noticeable because they differ from a person’s normal skin tone.
  4. They may be lighter, darker, or a different color, such as red, gray, or blue.

It is important that people with this symptom understand the cause of their discolored skin patches in case treatment is necessary. This article explores the various causes of discolored skin patches and explains which of them require treatment. Discolored skin patches have many different causes, including:

birthmarksskin pigmentation disordersskin rashesskin infections skin cancers medical conditions

We look at each one of these in more detail below.

What does spots on legs mean?

Frequently Asked Questions – What causes red spots on lower legs? There are several possible causes of red spots on legs, including eczema (atopic dermatitis), hives (urticaria), insect bites, and heat rash. If you’re unsure what’s causing your symptoms, contact a medical provider.

What do leukemia spots look like? Some people with acute promyelocytic leukemia develop small red dots under the skin (called petechiae) that are generally most noticeable on people with light skin tones. In people with darker skin tones, these spots may be darker or less noticeable. Why am I getting spots on my legs? Working with a healthcare professional is the best way to determine the exact cause of spots on your legs.

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Possible causes include eczema, hives, insect bites, heat rash, and more serious causes like skin cancer. What causes little red spots on legs? It can be difficult to discern what’s causing red spots on your legs. Possible causes include eczema, hives, insect bites, and heat rash.

  • However, some causes can be more serious.
  • If you’re unsure about what’s causing your symptoms, contact a medical provider.
  • Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only.
  • This information does not constitute and should not be relied on for professional medical advice.

Always talk to your doctor about the risks and benefits of any treatment.

What do liver spots look like on legs?

Sun-induced skin changes – liver spots; Senile or solar lentigo or lentigines; Skin spots – aging; Age spots Liver spots are flat, brown or black spots that can appear on areas of the skin that are exposed to the sun. They have nothing to do with the liver or liver function. Lentigos, sometimes called age spots or freckles, are a result of cumulative damage to the skin by sunlight. They consist of flat spots with increased pigmentation. Some lesions may be fairly light, while others are darker. The edges are seldom uniform. Lentigo, sometimes called age spots or freckles, are a result of cumulative damage to the skin by sunlight. They consist of flat spots with increased pigmentation. Some lesions may be fairly light while others are darker. They are seldom uniform in shape. In this picture, there is also redness (erythema).

Is leg discoloration serious?

If you have a vascular problem like venous insufficiency or high blood pressure, you’re also at risk of leg discoloration. When left untreated, leg discoloration can lead to more serious issues, including pain, leg ulcers, or infection.

What do age spots look like on your legs?

What are the symptoms of age spots? – Age spots look like oval or round flat brown, tan or black splotches on the skin. They are usually smooth to the touch and uniform in color. They vary in size from a few millimeters to two centimeters. Some patients have just a few, while others may have hundreds on their skin.

Do brown spots go away?

Once what’s causing the dark spots or patches is found and stopped, fading can take time. A spot that is a few shades darker than your natural skin color will usually fade within 6 to 12 months. If the color lies deep in your skin, however, fading can take years.

What vitamin helps dark spots on legs?

Which Vitamins Are Good For Lightening Dark Spots? – Skin whitening or lightening is the most effective way to lighten dark spots. Vitamins can be used to lighten your skin and lighten dark spots. Three of the best vitamins for lightening dark spots are vitamin C, vitamin B12, and vitamin E.

What are the brown spots on my lower legs and ankles?

Do you or someone you know have foot or ankle discoloration? Have you noticed swelling or indents from socks that worsen later in the day? These may be signs of Vein Disease. Areas of darker skin color in the lower leg, ankle or foot are called Hemosiderin deposits.

Can brown spots become cancerous?

Seeing spots? – If you’re over 50, you may notice spots appearing on the areas of your skin that are often exposed to the sun — like your face, hands, neck, etc. These spots are called “actinic lentigines,” which are more commonly referred to as sun spots, age spots, or liver spots.

When should I be worried about brown spots?

Age spots on the hand – Age spots may grow in size and group together, giving the skin a speckled or mottled appearance. They’re very common in areas that get repeated sun exposure, such as on the back of the hand. Age spots:

Are flat, oval areas of increased pigmentation Are usually tan to dark brown Occur on skin that has had the most sun exposure over the years, such as the backs of hands, tops of feet, face, shoulders and upper back Range from freckle size to about 1/2 inch (13 millimeters) across Can group together, making them more noticeable

Age spots don’t require medical care. Have your doctor look at spots that are black or have changed in appearance. These changes can be signs of melanoma, a serious form of skin cancer. It’s best to have any new skin changes evaluated by a doctor, especially if a spot:

Is black Is increasing in size Has an irregular border Has an unusual combination of colors Is bleeding

What deficiency causes brown spots?

Hyperpigmentation as a Primary Symptom of Vitamin B12 Deficiency: A Case Report Monitoring Editor: Alexander Muacevic and John R Adler 1 Internal Medicine, Ziauddin University, Karachi, PAK Find articles by 2 School of Medicine, University of Michigan, Ann Arbor, USA Find articles by 3 Internal Medicine, Ramaiah Medical College, Bangaluru, IND Find articles by 4 College of Medicine, Al-Quds University, Jerusalem, PSE Find articles by 5 Cardiovascular Medicine, University of Louisville School of Medicine, Louisville, USA Find articles by 6 Internal Medicine, University of Sulaimani, Sulaymaniyah, IRQ Find articles by 7 Acute Medicine, University Hospitals of Derby and Burton, Burton, GBR Find articles by 8 Internal Medicine, Akhtar Saeed Medical and Dental College, Lahore, PAK Find articles by © 2022, Jangda et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The presentation of vitamin B12 deficiency varies from being asymptomatic to affecting multiple organ systems.

In addition, several systemic diseases can be associated with generalized weakness and hyperpigmentation. However, vitamin B12 deficiency rarely presents with hyperpigmentation as an initial symptom. We present a rare case of a 22-year-old college student who presented with hyperpigmentation as the only physical manifestation of early vitamin B12 deficiency.

  1. This case underlines the need to rule out vitamin B12 deficiency when clinicians encounter hyperpigmentation as a solo presentation and also emphasizes the significance of early treatment in preventing the irreversible neurological manifestations of vitamin B12 deficiency.
  2. Eywords: cutaneous manifestation of vitamin b12 deficiency, adisonian mimick, vitamin b12 deficiency symptoms, cutaneous hyperpigmentation, hyperpigmentation The deficiency of vitamin B12 can cause specific skin manifestations, such as hyperpigmentation, vitiligo, angular stomatitis, and hair and nail changes,

However, the most common dermatological manifestation is hyperpigmentation, which often occurs in combination with systemic findings, including macrocytic anemia, pancytopenia, and subacute combined degeneration of the cord (SCD), When dermatological features occur in the dissociation of systemic findings, the deficiency of vitamin B12 can be overlooked.

  • As a result, such cases are rarely reported,
  • A 22-year-old male student presented with a four-month history of the progressive development of hyperpigmentation on his knuckles.
  • At first, he thought sun exposure was the primary cause, so he started wearing gloves during the day to prevent any exposure.

Nevertheless, his hyperpigmentation gradually worsened with time, involving his knuckles, dorsal aspect of interphalangeal joints, distal phalanges, and the foot (dorsal surface of interphalangeal joints). His fingernails and the palmar surfaces of his hands and feet were spared.

He denied the development of any rash or skin allergy before the onset of hyperpigmentation. Apart from hyperpigmentation being his only primary presentation, no other systemic complaints were present in the patient. His previous medical and medication history was unremarkable. He had never undergone any surgery and had never been on a restricted diet.

His BMI was 20, and his weight had been stable over the past 12 months. On examination, vital signs were stable with no pallor. However, considerable hyperpigmentation in the form of brownish discoloration was noted, which was more marked on the dorsal aspect of the hands (Figure ).

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There were no signs of hyperpigmentation in the oral cavity. A detailed systemic examination revealed no positive findings, including unremarkable neurological assessments. Based on the physical findings, the suspicion of autoimmune disorders was ruled out. Investigations were carried out primarily to rule out the systemic causes of hyperpigmentation.

Investigations included complete blood counts, serum electrolytes, 8 a.m. plasma cortisol levels, vitamin B12, and serum folic acid levels. His morning cortisol and serum electrolytes were within normal ranges, excluding adrenal insufficiency (Table ).

Lab parameters Value (normal range)
Hb (g/dL) 13.6 (13.5-17.5)
MCV (fl) 96.8 (80-100)
WBC (X10 9 /l) 7.2 (4.5-11)
Platelets (X10 3 /ul) 300 (150-400)
Serum Vitamin B12 (pg/mL) 125 (210-911)
Serum Iron (μg/dL) 110 (67-175)
Serum Folic Acid (ng/mL) 6.8 (2-20)
Serum Cortisol 8 a.m (μg/dL) 13.8 (5-23)
Na (mEq/L) 141 (136-146)
K (mEq/L) 3.8 (3.5-5)
Cl (mmol/L) 96 (95-105)

His serum vitamin B12 levels were 125 pg/mL (210-911 pg/mL). All other investigations were normal. He was diagnosed with one of the rare early manifestations of vitamin B12 deficiency, as all other causes for hyperpigmentation were ruled out other than low serum vitamin B12 levels. Treatment with intramuscular injection of vitamin B12 was initiated (1000 mcg IM twice a week for a month, plus 100 mcg orally per day). Further investigations were carried out to rule out pernicious anemia. Moreover, improvement was noticed within two weeks of initiating treatment (Figure ). Post-treatment improvement. At his second follow-up after three weeks, his vitamin B12 levels were over 300 pg/mL, and his hyperpigmentation was completely resolved. The antibody titer for pernicious anemia was also unremarkable, making a lack of vitamin B12 in the diet the sole cause of this occurrence. However, the oral dose of vitamin B12 of 100 mcg was continued for a month, and the patient was advised to increase their dietary intake of vitamin B12 from animal or fortified foods. Vitamin B12 plays an integral role in the synthesis of DNA; its deficiency results in multisystem complications, Plasma concentration below 200 pg/ml (148 pmol/L) is considered deficient. In the general population, the prevalence ranges from 3-5% to 5-20% among people aged >65 years, The deficiency affects all age groups and causes a range of conditions, most commonly affecting the hematological and neurological systems, The neurological complications include SCD, peripheral neuropathy, and psychiatric changes, Many mucocutaneous findings, including hair and nail changes and hyperpigmentation, especially of the hands and feet, are associated with vitamin B12 deficiency, Reversible skin and mucosal hyperpigmentation are the most commonly found skin manifestations of vitamin B12 deficiency, However, most cases present alongside systemic findings, such as malabsorption, anemia, pancytopenia, and variable neuropsychiatric problems, Interestingly Dr. Bramwell Cook defined a syndrome in late 1944 related to vitamin B12 deficiency, entailing hyperpigmentation, glossitis, and macrocytic megaloblastic anemia as its primary features. It has been observed that up to 1 in 5 patients with a deficient B12 level may have cutaneous hyperpigmentation, Rarely, as observed in this patient, has skin hyperpigmentation been reported as the only symptom of vitamin B12 deficiency, Other more common causes of hyperpigmentation include systemic causes, such as Addison disease, hyperthyroidism, hemochromatosis, and certain primary skin disorders. Protein-energy malnutrition, zinc deficiency, and pellagra can also cause hyperpigmentation, In one study, Baker SJ et al. observed that 21 patients who presented with other primary findings of vitamin B12 deficiency also had hyperpigmentation, Moreover, Aaron S et al. found that 41% (26 out of 63) of his patients presented with cutaneous changes as a primary symptom of vitamin B12 deficiency. While 52% of these 26 patients (22% of the total) presented with mucosal changes, glossitis was specifically seen in 31% (19 out of 63), hyperpigmentation of the skin in 19% (12 out of 63), hair changes in 9% (6 out of 63), angular stomatitis in 8% (5 out of 63), and lastly, vitiligo was seen in only 3% (2 out of 63), Therefore, regardless of the presence of neurological symptoms, SCD should be suspected in patients with skin hyperpigmentation, as the neurological manifestations can be a late finding, Skin hyperpigmentation in B12 deficiency was most commonly observed on the hands and feet (dorsal aspect), with the knuckles being the most prominent site. The darkening of sole and palmar creases, interphalangeal joints, and terminal phalanges was also observed, It remains questionable whether the development of hyperpigmentation is responsive to specific serum vitamin B12 levels, The pathophysiologic mechanism of hyperpigmentation involves increased melanin synthesis and the inadequate transfer of the pigment from the melanocytes to the nearby keratinocytes. Increased melanin synthesis occurs with the tyrosinase enzyme’s raised activity, The increase in melanin synthesis is considered the leading mechanism in lieu of inadequate melanin transfer, Electron microscopy showed the presence of extensive megaloblastic keratinocytes encircling the melanosomes containing melanocytes. The treatment consists of oral and/or parenteral vitamin B12 depending on the severity of symptoms and the level of deficiency. When hyperpigmentation is the primary presentation, oral treatment is preferred over parenteral treatment. The resolution period of the hyperpigmentation tends to vary from 6 to 12 weeks after the treatment, Recurrence of hyperpigmentation in our patient was not observed at a one-year follow-up. A thorough systemic examination should be performed in patients presenting with hyperpigmentation of the skin. It should be investigated for a deficiency of vitamin B12, besides ruling out the other common causes. Alongside providing adequate treatment, the patient should be followed up for a few weeks to examine for the resolution and screen for neurological manifestations, as there can be a late manifestation in some patients. The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. Cureus is not responsible for the scientific accuracy or reliability of data or conclusions published herein. All content published within Cureus is intended only for educational, research and reference purposes. Additionally, articles published within Cureus should not be deemed a suitable substitute for the advice of a qualified health care professional. Do not disregard or avoid professional medical advice due to content published within Cureus. The authors have declared that no competing interests exist. Consent was obtained or waived by all participants in this study 1. Cutaneous lesions and vitamin B12 deficiency: an often-forgotten link. Kannan R, Ng MJ., Can Fam Physician.2008; 54 :529–532.2. Skin hyperpigmentation as the presenting symptom of subacute combined degeneration of the spinal cord. Alhazmi A, Almalki A, Ghazala S. Case Rep Neurol Med.2017; 2017 :7140908.3. Knuckle pigmentation as an early cutaneous sign of vitamin B12 deficiency: a case report. Srivastava A, Choudhary S. JNMA J Nepal Med Assoc.2020; 58 :798–800.4. Vitamin B12 deficiency presenting with hyperpigmentation and pancytopenia. Rao VR. J Family Med Prim Care.2018; 7 :642–644.5. Reversible hyperpigmentation in vitamin B12 deficiency: an Addisonian mimic in clinical practice. Awindaogo RA, Ekem I, Awuku NA, et al. PAMJ Clin Med.2020; 4 :109.6. Vitamin B12 deficiency induces imbalance in melanocytes homeostasis-a cellular basis of hypocobalaminemia pigmentary manifestations. Rzepka Z, Respondek M, Rok J, Beberok A, Ó Proinsias K, Gryko D, Wrześniok D. Int J Mol Sci.2018; 19 7. A vitamin B deficiency syndrome allied to sprue. Cook AB. Ind Med Gaz.1944; 79 :429–437.8. Generalised hyperpigmentation in vitamin B12 deficiency. Santra G, Paul R, Ghosh SK, Chakraborty D, Das S, Pradhan S, Das A. J Assoc Physicians India.2014; 62 :714–716.9. Hyperpigmentation of skin. A sign of vitamin-B12 deficiency. Baker SJ, Ignatius M, Johnson S, Vaish SK. Br Med J.1963; 1 :1713–1715.10. Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromes. Aaron S, Kumar S, Vijayan J, Jacob J, Alexander M, Gnanamuthu C. Neurol India.2005; 53 :55–58.11. Hyperpigmentation with vitamin B12 deficiency in an adolescent girl. Hasan SH, Samad R, Das JC, Ara F. J Bangladesh Coll Phys Surg.2021; 39 :62–67. : Hyperpigmentation as a Primary Symptom of Vitamin B12 Deficiency: A Case Report

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Is it normal to get spots on your legs?

Eczema – A doctor may suggest various treatment options when treating eczema. Some typical treatments include:

antihistamines antibioticscorticosteroids

A doctor may be able to suggest strategies for avoiding the potential triggers. A person with eczema should also be aware of their increased susceptibility to skin infections and should avoid people with chickenpox or cold sores, Exposure to herpes simplex virus can lead to eczema herpeticum, which is a severe infection that spreads quickly.

worsening rash fever painred streaks coming from the pimplesblistersswelling around the pimples

Can stress cause spots on legs?

Hives caused by stress – Share on Pinterest Stress can play a big or small part in peoples daily lives, but it may also manifest in physical ways as well. Stress can trigger an outbreak of hives that can make up a stress rash. Hives are raised, red-colored spots or welts. They vary in size and can occur anywhere on the body.

cold or heat exposureinfectioncertain medications, including antibiotics

The most common cause of hives is an allergen entering the body. For example, an individual with hay fever may develop hives as a result of exposure to pollen. It is also possible for emotional stress to trigger an outbreak of hives. There can be a number of hormonal or chemical changes that occur in response to stress.

consumption of alcohol or caffeineexposure to warm temperatures

What causes spots on lower legs?

How can I prevent the most common causes of lower leg redness? – The most common causes of lower leg redness are likely mild trauma, sunburn, or mild infection. Preventing mild trauma can be done by wearing clothing that covers the legs and being careful to not over-exert yourself while exercising.

What food causes dark spots on skin?

There are many things that can harm the skin. The sun (specifically overexposure to UV rays) is an obvious culprit in causing damage, including premature aging, and skin cancer. We have also written about the negative affects of stress and hormonal imbalances, smoking, alcohol, and today we will discuss the impact diet and certain foods have on the skin.

Diet and the foods we eat are an often overlooked factor in the health and appearance of our skin. Certain foods can cause hyperpigmentation to worsen due to the compounds they contain and the hormonal changes they can trigger. At the same time, the right foods can help provide fantastic, hyperpigmentation-fighting nutrients to help keep the issue at bay.

For this reason, maintaining a well-balanced diet is crucial to keeping your skin happy and healthy. If you want to reduce the appearance of dark spots there are three types of food to steer clear of: sugary foods, fried foods, and foods that contain a lot of soy.

What is Strawberry legs?

What are strawberry legs? – Strawberry legs — also known as strawberry skin legs — occur when your hair follicles or pores are clogged with dirt, dead skin, bacteria or oil. The spots usually don’t itch or cause pain. The lighter your skin, the more visible strawberry legs are. You’ll typically see:

Black or brown spots after shaving. Open pores that look darker than usual, like blackheads. Pitted or dotted skin on your legs.

What vitamin deficiency causes brown spots on skin?

Discussion – Vitamin B12 deficiency causes a range of disorders and affects all age groups. The main systems affected in vitamin B12 deficiency are the hematologic, gastrointestinal, and nervous systems.1 The mucocutaneous manifestations of vitamin B12 deficiency are less common.

In 1944, Dr Bramwell Cook first observed that hyperpigmentation of the skin was associated with a macrocytic anemia and that both it and the anemia responded to crude liver extract.3 In patients with vitamin B12 deficiency, the following skin lesions are reported: skin hyperpigmentation, vitiligo, hair changes, and recurrent angular stomatitis.4 Hyperpigmentation of the extremities—especially over the dorsum of the hands and feet, with accentuation over the interphalangeal joints and terminal phalanges—associated with pigmentation of oral mucosa is characteristic of vitamin B12 deficiency.4 These signs can be observed in many other diseases with or without vitamin B12 deficiency.

Baker et al reported a series of 21 patients with vitamin B12 deficiency who had hyper-pigmentation of the skin.2 Aaron et al reported a series of 63 patients with vitamin B12 deficiency; 26 out of 63 (41%) patients had skin and mucosal changes.4 Glossitis (31%) was the most common mucocutaneous manifestation, followed by skin hyperpigmentation (19%), hair changes (9%), angular stomatitis (8%), and vitiligo (3%).

The hyperpigmentation noted by Aaron et al was an important general examination finding.4 The Case 1 patient had hyperpigmentation over the dorsum of all the toes, similar to the type of pigmentation described by Baker et al.2 There was no hyperpigmentation over palm creases and flexures. The hyperpigmentation related to vitamin B12 deficiency is more common in darker-skinned patients.

Few other cases of skin hyperpigmentation due to vitamin B12 deficiency have been reported in the literature.5 – 9 The mechanism of hyperpigmentation is due to increased melanin synthesis rather than a defect in melanin.10 In Case 2, the patient had skin lesions that were not pigmented.

How do I get rid of spots on my legs?

Use a chemical exfoliant –

This might sound a little scary, but relax! Using a body wash or serum with ingredients like salicylic acid or glycolic acid can help lift off the dead skin cells which lurk on the surface of our skin, help clean out pores and keep the skin clear.15

  1. What do liver spots look like on legs?

    Sun-induced skin changes – liver spots; Senile or solar lentigo or lentigines; Skin spots – aging; Age spots Liver spots are flat, brown or black spots that can appear on areas of the skin that are exposed to the sun. They have nothing to do with the liver or liver function. Lentigos, sometimes called age spots or freckles, are a result of cumulative damage to the skin by sunlight. They consist of flat spots with increased pigmentation. Some lesions may be fairly light, while others are darker. The edges are seldom uniform. Lentigo, sometimes called age spots or freckles, are a result of cumulative damage to the skin by sunlight. They consist of flat spots with increased pigmentation. Some lesions may be fairly light while others are darker. They are seldom uniform in shape. In this picture, there is also redness (erythema).

    What are the brown spots on my lower legs and ankles?

    Do you or someone you know have foot or ankle discoloration? Have you noticed swelling or indents from socks that worsen later in the day? These may be signs of Vein Disease. Areas of darker skin color in the lower leg, ankle or foot are called Hemosiderin deposits.